Ceramides and Dihydroceramides

Ceramides and their saturated analogs dihydroceramides exert numerous biological effects including induction of cell maturation, cell cycle arrest, terminal cell differentiation, cell senescence, cell death, and skin water-barrier function. Ceramides can also produce reactive oxygen species and stimulate phosphorylation of proteins making them important protein regulators. It is apparent from these effects that ceramide exists at the crux of several enzyme reaction cycles and that experiments involving sphingolipid functions call for control of all of the cycles and their branch-off points. Matreya is the major supplier of these ubiquitous lipids, which can be used as standards for analysis of tissues and identification and quantitation of major sphingolipids.

References:

  1. D. Mitroi et al., "SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production" Autophagy Vol. 13:5 pp. 885-899, 2017
  2. T. Sadowski et al., "Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry" Sci Rep. Vol. 7(7):43761, 1-11, 2017