Deuterated Ceramides

Stable isotope labeled lipids are ideal for studies involving the metabolism and metabolites of a cellular system and can be used for the quantitative evaluation of major lipid pathways.1 Lipidomics has shown great success in the use of deuterium labeled compounds in identifying and quantifying individual molecular species by the use of tandem mass spectrometry.2 Sphingolipidomics is the sphingolipid subfield of the greater lipidomic discipline and began to appear as a distinct entity around 2005.3,4 It is the determination of the complete sphingolipid profile of a given system and the metabolism and pathways of those sphingolipids.

References:

  1. Magkos, F. and Mittendorfer, B., “Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo” Clin Lipidol., Vol. 4 pp. 215–230, 2009
  2. Byun, H. and Bittman, R. Selective deuterium labeling of the sphingoid backbone: facile syntheses of 3,4, 5-trideuterio-D-erythro-sphingosine and 3-deuterio-D-erythro-sphingomyelin” Chem Phys Lipids, Vol. 163(8) pp. 809-813, 2010
  3. M. Maceyka et al., Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. Prostaglandins Other Lipid Mediat., Vol. 77 pp. 15–22, 2005
  4. Merrill et al., Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods, Vol. 36 pp. 207–224, 2005

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N-omega-CD3-Octadecanoyl-D-erythro-sphingosine

N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9

N-omega-CD3-Octadecanoyl-D-erythro-dihydrosphingosine