Conjugated Linoleic Acids (CLA) and Methyl Esters

Conjugated linoleic acids (CLAs) have been implicated in numerous physiological functions and have anti-carcinogenic, anti-atherogenic, and anti-inflammatory properties.1 In addition, they have been demonstrated to decrease low-density lipoprotein cholesterol and increase lean body mass. CLAs comprise a number of linoleic acid isomers with varying double bond positions and cis/trans configurations. The major natural CLA is cis-9,trans-11-octadecadienoic acid (c9,t11-CLA) which comprises over 90% of the CLAs in ruminant fats. The other major natural CLA isomer, trans-10,cis-12-octadecadienoic acid, has been implicated in anticarcinogenic activity; suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells; and exhibiting anti-atherogenic activity.2 When assimilated through the diet CLA can be found in the intestinal mucosa, liver, and adipose tissues. Recently the role of CLA in chronic inflammation has undergone renewed investigation. By using pure isomers a more defined role of each CLA specie can be measured. Matreya is proud to offer four highly purified CLA isomers for research and comparison studies.

References:

  1. C. Liew et al., Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenisis, Vol. 16 pp. 3037-3043, 1995
  2. Helen B. MacDonald, Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge. Journal of the American College of Nutrition, Vol. 19:90002 pp. 111S-118S, 2000

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9(Z),11(E)-Octadecadienoic acid (Na+ salt)





Methyl 9(Z), 11(Z)-octadecadienoate


Methyl 10(E), 12(Z)-octadecadienoate