Gangliosides

Gangliosides are acidic glycosphingolipids that contribute a substantial presence to the outer leaflet of the cell plasma membrane. This is especially apparent in neuronal cells of the central nervous system where they have vital roles as neurotransmitters and cellular regulators.1 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.2 Gangliosides have been implicated in numerous types of cancer where they are often over-expressed on the membrane surface.3 A deficiency in the enzymes responsible for metabolizing gangliosides allows them to accumulate to toxic levels in several lysosomal storage diseases including GM1 gangliosidosis, GM2 gangliosidosis, Tay-Sachs disease, and Sandhoff disease. Matreya now offers a number of high purity deuterated gangliosides which are ideal for mass spectrometry studies.4

References:

  1. T. Kolter "Ganglioside Biochemistry" International Scholarly Research Network, Vol. 2012 pp. 1-36, 2012
  2. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry "Role of tumor-associated gangliosides in cancer progression" Biochimie, Vol. 85 pp. 455-463, 2003
  3. P. Giussani et al., "Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance" International Journal of Molecular Sciences, Vol. 15 pp. 4356-4392, 2014
  4. J. Gu, C. Tifft and S. Soldin "Simultaneous quantification of GM1 and GM2 gangliosides by isotope dilution tandem mass spectrometry" Clinical Biochemistry, Vol. 41(6) pp. 413-417, 2008

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Fucosylated monosialoganglioside GM1 (NH4+salt)

Monosialoganglioside GM1 (NH4+ salt)



N-omega-CD3-Octadecanoyl monosialoganglioside GM1 (NH4+ salt)

N-Hexanoyl-biotin-monosialoganglioside GM1


N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+salt)

Monosialoganglioside GM3 (NH4+salt)

N-omega-CD3-Octadecanoyl monosialoganglioside GM3 (NH4+salt)


Disialoganglioside GD1a (NH4+salt)

Disialoganglioside GD1b (NH4+salt)




N-omega-CD3-Octadecanoyl disialoganglioside GD3

Trisialoganglioside GT1b (NH4+salt)