Adamantane Glycosphingolipids

Matreya offers several glycosphingolipids containing an adamantane acetyl group on the amine of the ceramide. By replacing the natural fatty acyl group of the ceramide with a rigid, three dimensional hydrocarbon frame, a novel class of glycosphingolipid is produced. This class of lipid demonstrates similar toxin interactions to natural glycosphingolipids with increased water solubility.1

Reference:

  1. C. Lingwood et al. “Adamantyl glycosphingolipids provide a new approach to the selective regulation of cellular glycosphingolipid metabolism” The Journal of Biological Chemistry, Vol. 286(24) pp. 21413-21426, 2011

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N-(1-Adamantaneacetyl)-galactosylceramide

N-(1-Adamantaneacetyl)-glucosylceramide

N-(1-Adamantaneacetyl)-ceramide trihexoside