Phosphatidylinositol Phosphates

The metabolism of inositol lipids is involved in the signal transduction of many hormones, neurotransmitters and growth factors.1,2,3 The role of 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG) as second messengers is well recognized. In another more recently discovered pathway the activation of phosphoinositide 3-kinase (PI3K) results in the formation of three novel phosphatidyl lipids phosphorylated at the D3 positions of the inositol ring: PI-3-P, PI-3,4-P2, and PI-3,4,5-P3. These D3 lipids are not known substrates for any of the phospholipase C enzymes and function as second messengers. Matreya's synthetic phosphatidylinositols and inositol phosphates are excellent tools for investigating these second messengers, understanding the enzyme mechanisms involved in phosphoinositide metabolism, and designing therapeutic pharmacological agents.

References:

  1. Bruce A. Fenderson, E. M. Eddy, Sen-Itiroh Hakomori "Glycoconjugate expression during embryogenesis and its biological significance" BioEssays, Vol. 12 pp. 173, 1990
  2. P.W. Majerus, "Inositol phosphate biochemistry" Annual Review of Biochemistry Vol. 61 pp. 225-250, 1992
  3. Ao-Lin Hsu, et al. "Novel Function of Phosphoinositide 3-Kinase in T Cell Ca2+ Signaling: A Phosphatidylinositol 3,4,5-Trisphostphate-Mediated Ca2+ Entry Mechanism" Journal of Biological Chemistry, Vol. 275 pp. 16242-16250, 2000

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Phosphatidylinositol 3-phosphate, dipalmitoyl, (NH4+ salt)

Phosphatidylinositol 3-phosphate, dipalmitoyl, (NH4+ salt)

Phosphatidylinositol tris-3,4,5 phosphate, dipalmitoyl, (Na+ salt)

Phosphatidylinositol tris-3,4,5 phosphate, dipalmitoyl, (Na+ salt)