2-Fluoropalmitic acid

CATALOG # 1717
Amount 25 mg
Price $220.00
Qty
 
2-Fluoropalmitic acid
  • Catalog #:1717
  • Scientific Name:2-Fluoropalmitic acid
    Activity: Acyl-CoA synthase inhibitor
  • Common Name:2-Fluoropalmitic acid
    Activity: Acyl-CoA synthase inhibitor
  • Empirical Formula:C16H31FO2
  • CAS#89270-22-4
  • SDSView Material Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:274
  • Unit:25 mg
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC
  • Melting Point:83-85°C
  • Solubility:chloroform,ethanol,methanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    2-Fluoropalmitic acid is a synthetic inhibitor of Palmitoyl-CoA formation by long chain acyl-CoA synthetase thereby inhibiting sphingosine biosynthesis and protein palmitoylation. This product is very useful in the investigation of sphingosine synthesis1, protein acylation2, and other biological mechanisms3. Other alpha-fluoro-fatty acids also inhibit their respective acyl-CoAs.4

    References:
    1. R. Soltysiak et al. “D,L-alpha-Fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells” Biochim Biophys Acta, Vol. 792(2) pp. 214-226, 1984
    2. J. Zhang et al. “Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signaling” Journal of Biochemistry, Vol. 343, 541-549, 1999
    3. G. DeJesus and O. Bizzozero “Effect of 2-Fluoropalmitate, Cerulenin and Tunicamycin on the Palmitoylation and Intracellular Translocation of Myelin Proteolipid Protein” Neurochemical Research, Vol. 27(12) pp. 1669-1675, 2002
    4. M. Grillo et al. “Effect of α-Fluorination of Valproic Acid on Valproyl-S-Acyl-CoA Formation in Vivo in Rats” Drug Metabolism and Disposition, Vol. 29(9) pp. 1210-1215, 2001