Anti-ganglioside GD1b (polyclonal antibody)

CATALOG # 1964
Amount 50 µl
Price $390.00
Qty
 
Anti-ganglioside GD1b (polyclonal antibody)
  • Catalog #:1964
  • Scientific Name:Anti-ganglioside GD1b (polyclonal antibody to GD1b, isotype IgG, IgM)
  • Common Name:Anti-ganglioside GD1b (polyclonal antibody to GD1b, isotype IgG, IgM)
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:n/a
  • Unit:50 µl
  • Solvent:none
  • Source:rabbit
  • Purity:serum, not purified
  • Analytical Methods:ELISA, TLC immunoblotting
  • Natural Source:rabbit
  • Solubility:water
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:Yes
  • Hazardous:No
  • Literature References:Application Notes:

    Anti-ganglioside GD1b (anti-GD1b) is very useful in the identification of disialoganglioside GD1b and in immunotargeting cells expressing disialoganglioside GD1b. Several gangliosides have been found to have elevated expressions in tumor cells. Many therapeutic treatments of tumor cells are being investigated using antibodies to target cells that express these elevated levels of gangliosides. GD1b may be a target molecule for autoantibodies in some patients with acute sensory ataxic neuropathy.3 Anti-GD1b has been found in some patients with Guillain–Barré syndrome (a disorder affecting the peripheral nervous system) and may contribute to the pathogenesis of sensory disturbance and demyelination.4

    References:
    1. H. Yoshino, et al. “Fucosyl-GM1 in Human Sensory Nervous Tissue Is a Target Antigen in Patients with Autoimmune Neuropathies” Journal of Neurochemistty, Vol. 61 pp. 658, 1993
    2. S. Kusunoki, et al. “Neuropathy and IgM paraproteinemia: Differential binding of IgM M-proteins to peripheral nerve glycolipids” Neurology, Vol. 37 pp. 1795, 1987
    3. C. Pan et al. “Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody” Neurology, vol. 57(7) pp. 1316-1318, 2001
    4. F. Notturno MD, C. Caporale MD, A. Uncini MD “Acute sensory ataxic neuropathy with antibodies to GD1b and GQ1b gangliosides and prompt recovery” Muscle & Nerve, Vol. 37(2) pg. 265–268, 2008