Anti-ganglioside asialo GM2 (polyclonal antibody)

CATALOG # 1951
Amount 50 µl
Price $335.00
Qty
 
Anti-ganglioside asialo GM2 (polyclonal antibody)
  • Catalog #:1951
  • Scientific Name:Anti-ganglioside asialo GM2 (polyclonal antibody)
  • Common Name:Polyclonal antibody to asialo GM2, isotype IgG/IgM
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Unit:50 µl
  • Solvent:none
  • Source:rabbit
  • Purity:serum, not purified
  • Analytical Methods:ELISA, TLC immunoblotting
  • Natural Source:rabbit
  • Solubility:water
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:Yes
  • Hazardous:Yes
  • Literature References:Application Notes:

    Anti-ganglioside asialo GM2 is very useful in the identification of ganglioside asialo GM2 and in immunotargeting cells expressing asialo GM2. Several gangliosides have been found to have an elevated expression in tumor cells. Many therapeutic treatments of tumor cells are being investigated using antibodies to target cells that express these elevated levels of gangliosides. Lymphoma has been shown to have an increased level of asialo GM2 and passive immunization with monoclonal immunoglobulin G3 antibodies to asialo GM2 has effectively suppressed tumor formation in these cells.3 Asialo- GM2 has been identified as a receptor for many types of bacteria including Neisseria gonorrhoeae and Haemophilus influenzae.

    References:
    1. H. Yoshino et al. “Fucosyl-GM1 in Human Sensory Nervous Tissue Is a Target Antigen in Patients with Autoimmune Neuropathies” Journal of Neurochemistty, Vol. 61 pp. 658, 1993
    2. S. Kusunoki et al. “Neuropathy and IgM paraproteinemia: Differential binding of IgM M-proteins to peripheral nerve glycolipids” Neurology, Vol. 37 pp. 1795, 1987
    3. W. Young Jr and S. Hakomori “Therapy of mouse lymphoma with monoclonal antibodies to glycolipid: selection of low antigenic variants in vivo” Science, Vol. 211:4481 pp. 487-489, 1981