Cholesterol

CATALOG # 1006
Amount 500 mg
Price $130.00
Qty
 
Cholesterol
  • Catalog #:1006
  • Scientific Name:Cholesterol
  • Common Name:Cholesterol
  • Empirical Formula:C27H46O
  • CAS#57-88-5
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:387
  • Unit:500 mg
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC, GC
  • Natural Source:ovine
  • Melting Point:147-148°C
  • Solubility:chloroform, ethanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Cholesterol is a sterol that is essential for all animal life, being critical for membrane permeability and fluidity and for many cellular functions. It is a sterol that is both synthesized in animals and also acquired from the diet. Phytosterols have been found to compete with cholesterol for absorption in the intestinal tract which results in a reduction of cholesterol absorption.1 Recently, the affect of Phytosterols on micellar cholesterol solubility in bile has been investigated demonstrating that stigmasterol combined with saturated fatty acids are effective at lowering cholesterol micelle solubility in vivo.4 Cholesterol has been found to be involved in the regulation of certain integral protein activities and in vascular function and it is the precursor of steroids, bile salts, and vitamin D. Cholesterol also has functions in intracellular transport, cellular signaling and nerve conduction.2 There has been evidence that demonstrates that there is a link between brain cholesterol and Alzheimer’s disease.3 A high level of serum cholesterol has been identified as an indicator for diseases such as heart disease. A recent study has found that cholesterol may affect the functions of Apolipoprotein C-III and Apolipoprotein E involved in the clearance of lipoprotein remnants.5

    References:
    1. R. Ostlund et al. “Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans” Am J Clin Nutr, Vol. 75(6) pp. 1000-1004, 2002
    2. D. Brown and E. London “Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts” Journal of Biological Chemistry, Vol. 275 pp. 17221-17224, 2000
    3. W. G. Wood et al. “Recent Advances in Brain Cholesterol Dynamics: Transport, Domains, and Alzheimer’s Disease” Lipids, Vol. 34(3) pp. 225-234, 1999
    4. A. Brown et al. “Phytosterol Ester Constituents Affect Micellar Cholesterol Solubility in Model Bile” Lipids, Vol. 45(9) pp. 855-862, 2010
    5. S. Morita et al. “Presence of Apolipoprotein C-III Attenuates Apolipoprotein E-Mediated Cellular Uptake of Cholesterol-Containing Lipid Particles by HepG2 Cells” Lipids, DOI 10.1007/s11745-010-3498-9, 2010