Coprostanol

CATALOG # 1116
Amount 25 mg
Price $240.00
Qty
 
Coprostanol
  • Catalog #:1116
  • Scientific Name:Coprostanol
  • Common Name:5-beta-Cholestan-3-beta-ol
  • Empirical Formula:C27H48O
  • CAS#360-68-9
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:389
  • Unit:25 mg
  • Solvent:none
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:GC
  • Melting Point:101-103°C
  • Solubility:chloroform, ethyl ether, warm methanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Coprostanol is formed via the biohydrogentaion of cholesterol in many animals by intestinal bacteria. It is widely used as a biomarker for human fecal matter in the environment, especially in regards to sewage pollution of water sources.1 Coprostanol can be converted to coprostanone, another important fecal biomarker. Whereas many sterols are found esterified in vivo rather than as free sterols, coprostanol is not usually found esterified and is absorbed through the intestine as a free sterol.2 After absorption through the intestine a small amount of coprostanol is converted to acidic, neutral, and water soluble compounds.3 This product is a high purity sterol that is ideal as an analytical standard.4

    References:
    1. P. Nichols et al. “Comparison of the abundance of the fecal sterol coprostanol and fecal bacterial groups in inner-shelf waters and sediments near Sydney, Australia” Journal of Chromatography A, vol. 643(1-2) pp. 189-195, 1993
    2. R. Rosenfeld, B. Zumoff, and L. Hellman “Metabolism of coprostanol-C14 and cholestanol-4-C14 in man” Journal of Lipid Research, vol. 4(3) pp. 337- 340, 1963
    3. R. Bell et al. “Bile Acids” Journal of Biological Chemistry, vol. 240(3) pp. 1054-1058, 1965
    4. L. Jayasinghe et al. “Application of pentafluorophenyldimethylsilyl derivatization for gas chromatography–electron-capture detection of supercritically extracted sterols” Journal of Chromatography A, vol. 809 pp. 109-120, 1998