Fucosylated monosialoganglioside GM1 (NH4+salt)

CATALOG # 1526
Amount 500 ug
Price $595.00
Qty
 
Fucosylated monosialoganglioside GM1 (NH4+salt)
  • Catalog #:1526
  • Scientific Name:Fucosylated monosialoganglioside GM1 (NH4+ salt)
  • Common Name:Fucosyl-GM1
  • Empirical Formula:C79H141N3O35•NH3 (stearoyl) Typical fatty acid content
  • CAS#71812-11-8
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1693 + NH3 (stearoyl)
  • Unit:500 ug
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Natural Source:porcine
  • Solubility:chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis. Fucosyl-GM1 is a tumor associated ganglioside and is an antigen expressed in small cell lung cancer that is being investigated as a target for vaccines against cancer cells.3 It has been found that Fucosyl-GM1 demonstrates some of the same binding properties as the similar GM1 ganglioside such as affinity for cholera toxin B subunit and interaction with amyloid-beta protein.4

    References:
    1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
    2. T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002
    3. G. Ragupathi et al. “Immunization of mice with fucosyl-GM1 conjugated with keyhole limpet hemocyanin results in antibodies against human small-cell lung cancer cells” Cancer Immunology, Immunotherapy, Vol. 48 pp. 483-492, 1999
    4. M. Yanagisawa, T. Ariga, R. Yu “Fucosyl-GM1 expression and amyloid-ß protein accumulation in PC12 cells” Journal of Neuroscience Research, Vol. 84 pp. 1343-1349, 2006