L-threo-Dihydrosphingosine (Safingol)

CATALOG # 1807-025
Amount 25 mg
Price $725.00
Qty
 
C18H39NO2
  • Catalog #:1807-025
  • Scientific Name:L-threo-Dihydrosphingosine (Safingol)
  • Common Name:L-threo-Sphinganine, C18 chain
    Activity: Protein Kinase C (PKC) and Sphingosine Kinase inhibitor
  • Empirical Formula:C18H39NO2
  • CAS#15639-50-6
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:301
  • Unit:25 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC
  • Melting Point:103-114°C
  • Solubility:chloroform, methanol, ethanol, DMSO
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:
    1. Darges, et al. “Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine” Adv. Exp. Med. Biol, Vol. 400A pp. 387-392, 1997
    2. G. Schwartz, et al. “A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin” Clin. Cancer Res, Vol. 3 pp. 537-543, 1997
    3. J. Coward et al. “Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway” Autophagy Vol. 5(2) pp.184-193, 2009
    4. M. Dragusin et al. “Metabolism of the unnatural anticancer lipid safingol,L-threo-dihydrosphingosine, in cultured cells” Vol. 44 pp. 1772, 2003