L-threo-PDMP

CATALOG # 1749
Amount 10 mg
Price $390.00
Qty
 
L-threo-PDMP
  • Catalog #:1749
  • Scientific Name:L-threo-PDMP
  • Common Name:L-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol•HCl
  • Empirical Formula:C23H38N2O3•HCl
  • CAS#109836-81-9
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:427
  • Unit:10 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC
  • Solubility:ethanol, methanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:
    1. R. Vunnam, N. Radin “Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain” Chem Phys Lipids, Vol. 26(3) pp. 265-278, 1980
    2. N. Radin et al. “Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells” Journal of Cellular Physiology, Vol. 141(3) pp. 573–583, 1989
    3. J. Inokuchi, S. Usuki and M. Jimbo “Stimulation of Glycosphingolipid Biosynthesis by L-Threo-1-Phenyl-2-Decanoylamino-1-Propanol and Its Homologs in B16 Melanoma Cells” J. Biochem, Vol. 117(4) pp. 766-773, 1995
    4. N. Radin, et al. “Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth” Journal of Lipid Research, Vol. 36 pp. 611-621, 1995
    5. D. Sillance et al. “Glucosylceramide modulates membrane traffic along the endocytic pathway” Journal of Lipid Research, Vol. 43 pp. 1837-1845, 2002