Monosialoganglioside GM1 (NH4+salt) (50mg)

CATALOG # 1061-50
Amount 50 mg
Price $2,450.00
Qty
 
Monosialoganglioside GM1 (NH4+ salt)
  • Catalog #:1061-50
  • Scientific Name:Monosialoganglioside GM1(NH4+salt)
  • Common Name:GM1
  • Empirical Formula:C73H131N3O31•NH3 (stearoyl) Typical fatty acid content
  • CAS#37758-47-7
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1547+NH3 (stearoyl)
  • Unit:50 mg
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Natural Source:bovine brain
  • Solubility:chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF) by directly and tightly associating with Trk, the high-affinity tyrosine kinase-type receptor for NGF. It is the specific cell surface receptor for cholera toxin.4

    References:
    1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
    2. T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002
    3. S. Birkle, G. Zeng, L. Gao, R. K. Yu, and J. Aubry. Role of tumor-associated gangliosides in cancer progression. Biochimie, 85, 455–463, 2003
    4. C. E. Miller, J. Majewski, R. Faller, S. Satija, and T. L. Kuhl, Cholera Toxin Assault on Lipid Monolayers Containing Ganglioside GM1. Biophysj., June Vol. 86(6), 3700–3708, 2004