Monosialoganglioside GM4 (NH4+ salt)

CATALOG # 1535
Amount 500 µg
Price $450.00
Qty
 
Monosialoganglioside GM4 (NH4+ salt)
  • Catalog #:1535
  • Scientific Name:Monosialoganglioside GM4 (NH4+ salt)
  • Common Name:GM4
  • Empirical Formula:C57H106N2O17•NH3 (2-hydroxydocosanoyl) Typical fatty acid content
  • CAS#66456-69-7
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1091+ NH3 (2-hydroxydocosanoyl)
  • Unit:500 µg
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC
  • Natural Source:egg, chicken
  • Solubility:chloroform/methanol, 2:1; forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. GM4 is a monosialoganglioside located primarily in the central nervous system and was found to be a major component of myelin gangliosides.4 It was also found to be a specific marker for human myelin and oligodendroglial perikarya. However, in chicken cerebellum, GM4 is associated with astrocytes, and not with myelin. GM4 has been found to be the major ganglioside in chicken egg yolk, chicken embryonic liver, and frog liver.

    References:
    1. L. Svennerholm et al. (eds.), “Structure and Function of Gangliosides” New York, Plenum, 1980
    2. T. Kolter, R. Proia, K. Sandhoff, “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277:29, pp. 25859-25862, 2002
    3. S. Birkle et al. “Role of tumor-associated gangliosides in cancer progression” Biochimie, Vol. 85 pp. 455–463, 2003
    4. Li et al. “Association of GM4 ganglioside with the membrane surrounding lipid droplets in shark liver” Journal of Lipid Research, Vol. 43 pp. 1019-1025, 2002