N-Dodecanoyl-NBD-L-threo-dihydrosphingosine

CATALOG # 1623
Amount 100ug
Price $200.00
Qty
 
N-Dodecanoyl-NBD-L-threo-dihydrosphingosine
  • Catalog #:1623
  • Scientific Name:N-Dodecanoyl-NBD-L-threo-dihydrosphingosine
  • Common Name:N-C12:0-NBD-Dihydroceramide; N-C12:0-NBD-L-threo-Dihydrosphingosine
  • Empirical Formula:C36H63N5O6
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:662
  • Unit:100ug
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC
  • Solubility:methanol, chloroform/methanol, 2:1
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:
    1. Darges, et al. “Inhibition of leukotriene B4 (LTB4) in human neutrophils by L-threo-dihydrosphingosine” Adv. Exp. Med. Biol, Vol. 400A pp. 387-392, 1997
    2. G. Schwartz, et al. “A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin” Clin. Cancer Res, Vol. 3 pp. 537-543, 1997
    3. J. Coward et al. “Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway” Autophagy Vol. 5(2) pp.184-193, 2009
    4. M. Dragusin et al. “Metabolism of the unnatural anticancer lipid safingol,L-threo-dihydrosphingosine, in cultured cells” Vol. 44 pp. 1772, 2003