N-Hexadecanoyl-sulfatide

CATALOG # 1875
Amount 1 mg
Price $400.00
Qty
 
N-Hexadecanoyl-sulfatide
  • Catalog #:1875
  • Scientific Name:N-Hexadecanoyl-sulfatide
  • Common Name:N-C16:0-Sulfatide; N-Palmitoyl-sphingosyl-beta-D-galactoside-3-sulfate; N-Palmitoyl-sulfatide
  • Empirical Formula:C40H77NO11S
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:780
  • Unit:1 mg
  • Solvent:none
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC, identity confirmed by MS
  • Natural Source:bovine
  • Solubility:chloroform/methanol, 2:1
  • Physical Appearance:solid
  • Storage:-20°C
  • Composition:like 1049 but with defined C16 fatty acid side chain
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Sulfatide is a type of sulfolipid that is found primarily in the central nervous system and is a myelin-specific sphingolipid. A deficiency of sulfatide in white and gray matter has been associated with Alzheimer’s disease and other types of dementia. Apoliprotein E plays an important regulating role in the metabolism of sulfatides.1 A production of anti-sulfatide antibodies in the cerebrospinal fluid, leading to a deficiency in sulfatides, may be a cause of degeneration of the myelin sheath, leading to multiple sclerosis.2 Metachromatic leukodystrophy is an inherited disorder characterized by a deficiency of the lysosomal enzyme arylsulfatase A and the subsequent accumulation of sulfatide in neural and visceral tissues.3 An immunomodulatory role for sulfatides has been suggested in the pathogenesis of tuberculosis.

    References:
    1. H. Cheng, Y. Zhou, D. Holtzman, X. Han, Neurobiology of Aging, 2008
    2. R. Halder, A. Jahng, I. Maricic and Vipin Kumar, Neurochemical Research, February, Vol. 32(2) pp. 257, 2007
    3. P. Whitfield et al., Molecular Genetics and Metabolism, Vol. 73(1) pp. 30, 2001