Octadecatrienoic acid (all cis-9,12,15)

CATALOG # 1026
Amount 500 mg
Price $155.00
Qty
 
Octadecatrienoic acid (all cis-9,12,15)
  • Catalog #:1026
  • Scientific Name:Octadecatrienoic acid (all cis-9,12,15)
  • Common Name:alpha-Linolenic acid; C18:3 (all cis-9,12,15) Fatty acid
  • Empirical Formula:C18H30O2
  • CAS#463-40-1
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:278
  • Unit:500 mg
  • Solvent:none
  • Source:natural
  • Purity:99%
  • Analytical Methods:GC, TLC
  • Natural Source:plant
  • Solubility:chloroform, hexane, ethyl ether
  • Physical Appearance:liquid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    This polyunsaturated fatty acid is ideal as a standard and for biological studies. The thylakoid membranes of photosynthetic plants as well as many seed oils are rich in linolenic acid. It is an essential fatty acid in animals and has been attributed to many vital processes. Linolenic acid is converted in vitro to EPA, DPA, and DHA in animals, each of which has many beneficial functions.1 There is evidence that it is able to help reduce inflammation and prevent coronary heart disease2 although these are still being investigated. Low levels of linolenic acid in animals results in significant deviations in polyunsaturated fatty acid composition and a marked decrease in cervonic acid (DHA). Recovery from this deficiency is very slow when linolenic acid intake is increased. Linolenic acid helps to decrease mortality from toxic substances, maintains activity of the Na+ and K+ ATPase enzymes in animals (which control the ionic flow resulting from nerve transmission) and is critical in maintaining other enzyme activity. A lack of enzyme activity from linolenic acid deficiency leads to a decrease in learning ability. The retina is very rich in n-3 polyunsaturated fatty acids including linolenic acid and a deficiency in this fatty acid alters the electroretinogram resulting in decreased eye function.3

    References:
    1. G. Burdge and S. Wootton “Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women” British Journal of Nutrition, Vol. 88 pp. 411-420, 2002
    2. M. Lorgeril et al. “Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease” The Lancet, Vol. 343(8911) pp. 1454- 1459, 1994
    3. J. Bourre et al. “The Effects of Dietary a-LJnolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats” American Institute of Nutrition, Vol. 119(12) pp. 1880- 1892, 1989