Phosphatidylinositol tris-3,4,5-phosphate, dipalmitoyl, (Na+salt) (1mg)

CATALOG # 1775-1
Amount 1 mg
Price $375.00
Qty
 
Phosphatidylinositol tris-3,4,5 phosphate, dipalmitoyl, (Na+ salt)
  • Catalog #:1775-1
  • Scientific Name:Phosphatidylinositol tris-3,4,5-phosphate, dipalmitoyl, (Na+salt)
  • Common Name:DPPI-3,4,5,-P3; PI-3,4,5-P3 dipalmitoyl, (Na+salt)
  • Empirical Formula:C41H75O22P4 •7Na
  • CAS#165689-82-7
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1205
  • Unit:1 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:1H NMR, 31P NMR
  • Solubility:water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No
  • Literature References:Application Notes:

    Phosphatidylinositol polyphosphates are very important in cellular signaling and have been shown to mediate a large number of physiological processes by attracting proteins to specific cellular sites. Phosphatidylinositol-(4,5)-bisphosphate is phosphorylated by phosphoinositide-3-kinase to produce Phosphatidylinositol-(3,4,5)-trisphosphate (PIP3).1 PIP3 is a second messenger that has a central role in cell growth, programmed cell death, spindle orientation control, and directed cell migrations such as chemotaxis. The Akt/PKB signaling pathway leads to cell survival and growth and is activated by PIP3. The PTEN protein regulates the Akt/PKB pathway by dephosphorylating PIP3. Many types of tumors show a mutation in the PTEN gene, showing a direct correlation between cancer and over expression of PIP32. PIP3 accumulates in the plasma membrane and acts as a site-specific receptor to recruit and activate proteins. It controls many cellular processes by generating internal calcium signals3 and it can directly modulate the activity of ion channels including the epithelial Na+ channel.4

    References:
    1. P. Majerus “Inositol phosphate biochemistry” Annual Review of Biochemistry, Vol. 61 pp. 225-250, 1992
    2. N. Leslie, X. Yang, C. Downes, and C. Weijer “PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration” Current Biology, Vol. 17(2) pp. 115-125, 2007
    3. A. Hsu et al. “Novel Function of Phosphoinositide 3-Kinase in T Cell Ca2+ Signaling: A Phosphatidylinositol 3,4,5-Trisphostphate-Mediated Ca2+ Entry Mechanism” Journal of Biological Chemistry, Vol. 275 pp. 16242-16250, 2000
    4. O. Pochynyuk et al. “Identification of a Functional Phosphatidylinositol 3,4,5-Trisphosphate Binding Site in the Epithelial Na+ Channel” Journal of Biological Chemistry, Vol. 280 pp. 37565-37571, 2005