CUSTOMER SERVICE  |  814.355.1030  |  Toll Free: 800.342.3595  |  M-F: 8am-4pm EST/EDT

Sulfatides (Sulfogalactosylceramides)

A sulfatide is a type of sulfolipid that is found primarily in the central nervous system and is a myelin-specific sphingolipid. A deficiency of sulfatides in white and gray matter has been associated with Alzheimer’s disease and other types of dementia. Apoliprotein E plays an important regulating role in the metabolism of sulfatides.1 The production of anti-sulfatide antibodies in the cerebrospinal fluid, resulting in a deficiency of sulfatides, may cause degeneration of the myelin sheath leading to multiple sclerosis.2 Metachromatic leukodystrophy is an inherited disorder characterized by a deficiency of the lysosomal enzyme arylsulfatase A and the subsequent toxic accumulation of sulfatide in neural and visceral tissues.3 An immunomodulatory role for sulfatides has been suggested in the pathogenesis of tuberculosis.

References:

  1. H. Cheng, Y. Zhou, D. M. Holtzman, X. Han “Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease.” Neurobiology of Aging, Vol. 31(7):1188-1196 2010
  2. Ramesh C. Halder, A. Jahng, I. Maricic and Vipin Kumar “Mini Review: Immune Response to Myelin-Derived Sulfatide and CNS-Demyelination” Neurochemical Research, Vol. 32(2): 257, 2007
  3. Phillip D. Whitfield, Peter C. Sharp, David W. Johnson, Paul Nelson and Peter J. Meikle “Characterization of Urinary Sulfatides in Metachromatic Leukodystrophy Using Electrospray Ionization-Tandem Mass Spectrometry” Molecular Genetics and Metabolism, Vol. 73(1): 30, 2001

Catalog #: 1049
CAS#: 85496-63-5
Unit: 50 mg
$619.00
Catalog #: 1904
CAS#: 1246681-32-2
Unit: 1 mg
$673.00
Catalog #: 2092
CAS#:
Unit: 1 mg
$486.00
Catalog #: 2076
CAS#: 252846-08-5
Unit: 1 mg
$476.00
Catalog #: 1938
CAS#: 852100-88-0
Unit: 1 mg
$476.00
Catalog #: 1875
CAS#: 89771-78-8
Unit: 1 mg
$476.00
Catalog #: 1934
CAS#: 1071654-84-6
Unit: 1 mg
$476.00
Catalog #: 1932
CAS#: 244215-65-4
Unit: 1 mg
$476.00
Catalog #: 1933
CAS#:
Unit: 1 mg
$476.00
Catalog #: 1935
CAS#:
Unit: 1 mg
$476.00
Catalog #: 1888
CAS#: 151122-71-3
Unit: 1 mg
$476.00
Catalog #: 1931
CAS#: 151057-28-2
Unit: 1 mg
$476.00
Catalog #: 1536
CAS#:
Unit: 1 mg
$654.00
Catalog #: 1632
CAS#:
Unit: 100 ug
$203.00
Catalog #: 1632-001
CAS#:
Unit: 1 mg
$535.00
Catalog #: 2207
CAS#:
Unit: 1 mg
$535.00
Catalog #: 1540
CAS#: 1292769-63-1
Unit: 1 mg
$416.00
Sign up for news & updates! Sign up!
Please Wait... processing