CUSTOMER SERVICE  |  814.355.1030  |  Toll Free: 800.342.3595  |  M-F: 8am-4pm EST/EDT

2-Hydroxytetradecanoic acid

CATALOG # 1703


  • Catalog #:1703
  • Scientific Name:2-Hydroxytetradecanoic acid
  • Common Name:2-Hydroxy C14:0 fatty acid
  • Empirical Formula:C14H28O3
  • CAS#:2507-55-3
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:244
  • Unit:50 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC; GC; identity confirmed by MS
  • Melting Point:81-82°C
  • Solubility:methanol, chloroform
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

This product is a high purity 2-hydroxy fatty acid that is ideal as a standard and for biological systems. alpha-Hydroxy fatty acids are abundant in nervous tissues and are components of cerebrosides and sulfatides, which are mostly found in the myelin of nervous tissues. They are common in cosmetics and skin creams and lotions. 2-Hydroxytetradecanoic acid is formed by the oxidation of tetradecanoic acid by the enzyme fatty acid 2-hydroxylase. This enzyme is also responsible for the formation of 2-hydroxy galactolipids in the peripheral nervous system.1 2-Hydroxytetradecanoic acid can form 2- hydroxymyristoyl-CoA which is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase, the enzyme that catalyzes protein N-myristoylation, and can be used to reduce the amount of p56lck (a protein-tyrosine kinases) at the plasma membrane.2 2-Hydroxytetradecanoic acid, but not other 2-hydroxy acids or any 3-hydroxy acids, was found to stimulate an increase in elongated lateral branches of some fungi.3 alpha-Oxidation of 2-hydroxy fatty acids to CO2 and saturated acids occurs in the peroxisome and is unique from the alpha-oxidation of beta-carbon branched fatty acids such as phytanic acid. Cells from Zellweger syndrome and peroxisome-deficient cells are unable to undergo alpha-oxidation although patients with other peroxisomal disorders such as X-linked adrenoleukodystrophy, Refsum disease, and rhizomelic chondrodysplasia punctata are able.4

1. C. Lendrum et al. “Nonequilibrium 2-Hydroxyoctadecanoic Acid Monolayers: Effect of Electrolytes” Langmuir, vol. 27 pp. 4430-4438, 2011
2. J. Sjogren et al. “Antifungal 3-Hydroxy Fatty Acids from Lactobacillus plantarum MiLAB 14” Applied and Environmental Microbiology, vol. 69 pp. 7554-7557, 2003
3. G. Nagahashi and D. Douds Jr. “The effects of hydroxy fatty acids on the hyphal branching of germinated spores of AM fungi” Fungal Biology, vol. 115 pp. 351-358, 2011
4. R. Sandhir, M. Khan, and I. Singh “Identification of the Pathway of alpha-Oxidation of Cerebronic Acid in Peroxisomes” Lipids, Vol. 35(10) pp. 1127-1133, 2000
Price $185.00

Related Products

Catalog #: 1704
CAS#: 56009-40-6
Unit: 50 mg

Others Also Bought

Catalog #:
Catalog #: 1727
CAS#: 14292-26-3
Unit: 25 mg
Catalog #: 1735
CAS#: 3422-31-9
Unit: 25 mg

Customer Reviews

Average Rating
Sign up for news & updates! Sign up!
Please Wait... processing