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22-Hydroxydocosanoic acid

CATALOG # 1818

Specifications

  • Catalog #:1818
  • Scientific Name:22-Hydroxydocosanoic acid
  • Common Name:omega-Hydroxy C22:0 fatty acid
  • Empirical Formula:C22H44O3
  • CAS#:506-45-6
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:356
  • Unit:25 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC, identity confirmed by MS
  • Melting Point:100-102°C
  • Solubility:chloroform/methanol, 2:1
  • Physical Appearance:solid
  • Storage:room temperature
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

This product is a high purity omega-hydroxy long chain fatty acid that is ideal as a standard and for biological studies. Omega-oxidation is a minor fatty acid pathway used for fatty acid metabolism and usually occurs in the smooth endoplasmic reticulum. Docosanoic acid is enzymaticaly converted to the 22-hydroxydocosanoic acid as well as to the docosanoic dicarboxylic acid as part of the omega-oxidation metabolic pathway.1 22-Hydroxydocosanoic acid is the major aliphatic constituent of green cotton fibers but a very minor component of white cotton fibers.2 Stimulation of omega-hydroxylation has been proposed as a method for treating X-linked adrenoleukodystrophy, a disease that is characterized by elevated levels of very long chain fatty acids.3

References:
1. R. Sanders et al. “Evidence for two enzymatic pathways for omega-oxidation of docosanoic acid in rat liver microsomes” Journal of Lipid Research, Vol. 46(5) pp. 1001-1008, 2005
2. L. Yatsu, K. Espelie, P. Kolattukudy “Ultrastructural and chemical evidence that the cell wall of green cotton fiber is suberized” Plant Physiology, Vol. 73(2) pp. 521-524, 1983
3. R. Sanders et al. “Omega-Oxidation of Very Long-Chain Fatty Acids in Human Liver Microsomes: Implications for X-Linked Adrenoleukodystrophy” Journal of Biological Chemistry, Vol. 281 pp. 13180-13187, 2006
Price $297.00

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