Application Notes:
This 3-hydroxydecanoic acid is a high purity standard that is useful for the investigation of disorders and diseases.
Polyhydroxyalkenoates, polyesters produced by bacteria fermentation, such as from Escherichia coli, are used for carbon and
energy storage and are of interest in studies regarding their synthesis, properties and mechanisms.1 Short chain-length
polyhydroxyalkenoate monomers such as 3-hydroxydecanoic acid may have pharmaceutical properties. 3-Hydroxydecanoic
acid is the prevalent fatty acid in the rhamnolipid of Pseudomonas aeruginosa.2 The biologically natural chiral (R)-3-
hydroxydecanoic acid is an intermediate in fatty acid biosynthesis. 3-hydroxy fatty acids are used as biomarkers for fatty acid
oxidative disorders of both the long- and short-chain 3-hydroxy-acyl-CoA dehydrogenases.3,4
References:
1. Z. Zheng et al. “Production of 3-hydroxydecanoic acid by recombinant Escherichia coli HB101 harboring phaG gene” Antonie Van Leeuwenhoek, vol. 85
pp. 93-101, 2004
2. Q. Wang et al. “Engineering Bacteria for Production of Rhamnolipid as an Agent for Enhanced Oil Recovery” Biotechnology and Bioengineering, vol. 98
pp. 842-853, 2007
3. P. Jones et al. “Improved Stable Isotope Dilution-Gas Chromatography-Mass Spectrometry Method for Serum or Plasma Free 3-Hydroxy-Fatty Acids and
Its Utility for the Study of Disorders of Mitochondrial Fatty Acid ß-Oxidation” Clinical Chemistry, vol. 46, pp. 149-155, 2000
4. P. Jones et al. “Accumulation of free 3-hydroxy fatty acids in the culture media of fibroblasts from patients deficient in long-chain l-3-hydroxyacyl-CoA
dehydrogenase: a useful diagnostic aid” Clinical Chemistry, vol. 47(7) pp. 1190-1194, 2001