Application Notes:
This 3-hydroxynonanoic acid is a high purity standard that is useful for the investigation of disorders and diseases. 3-
Hydroxy fatty acids are intermediates in fatty acid biosynthesis and have been found to be converted to the omega-fatty acid
by the enzyme CYP4F11 and then into dicarboxylic acids in vivo.1 3-Hydroxy fatty acids are used as biomarkers for fatty
acid oxidative disorders of both the long- and short-chain 3-hydroxy-acyl-CoA dehydrogenases.2 Polyhydroxyalkenoates of
3-hydroxy fatty acids are polyesters produced by bacteria fermentation and are used for carbon and energy storage. These
polyhydroxyalkenoates are of interest in studies regarding the synthesis, properties and mechanisms of bacteria. Short chainlength
polyhydroxyalkenoate monomers such as 3-hydroxy fatty acids may have pharmaceutical properties.3
References:
1. M. Dhar et al. “Omega-oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11” Journal of Lipid Research, vol. 49, pp. 612-624, 2008
2. P. Jones et al. “Accumulation of free 3-hydroxy fatty acids in the culture media of fibroblasts from patients deficient in long-chain l-3-hydroxyacyl-CoA dehydrogenase: a useful diagnostic aid” Clinical Chemistry, vol. 47(7) pp. 1190-1194, 2001
3. J. Gangoiti et al. “Production of Chiral (R)-3-Hydroxyoctanoic Acid Monomers, Catalyzed by Pseudomonas fluorescens GK13 Poly(3-Hydroxyoctanoic Acid) Depolymerase” Applied and Environmental Microbiology, vol. 76 pp. 3554-3560, 2010