Application Notes:
9(Z),11(E)-Octadecadienoic acid is a conjugated linoleic acid (CLA), an isomer of linoleic acid. CLA is found mostly in
lipids originating in ruminant animals including dairy products. It has several biological properties including anticarcinogenic
activity, suppressing in vitro growth of human melanoma, colorectal, and breast cancer cells, and exhibiting
anti-atherogenic activity.1 It is thought that CLA itself may not have anti-oxidant capabilities but may produce substances
which protect cells from the detrimental effects of peroxides. 9(Z),11(E)-Octadecadienoic acid is the major natural isomer of
CLA constituting 73% to 93% of the total CLA in dairy products2 and it appears to be the most biologically active isomer. It
appears to enhance animal growth and inhibit osteoclast formation and activity from human cells,3 as well as decrease
LDL:HDL and total HDL:cholesterol levels in humans.4
References:
1. Helen B. MacDonald, Journal of the Amer. College of Nutr., Vol 19, No. 90002, 111S-118S, 2000
2. M. Belury, Annual Review of Nutrition, July Vol.22, 505, 2002
3. Ilana Platt, Ahmed El-Sohemy, Lipids in Health and Disease, 8:15, 2009
4. S. Tricon, et al., The American Journal of Clinical Nutrition, 80:614, 2004