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CATALOG # 1845


  • Catalog #:1845
  • Scientific Name:D-erythro-C20-Dihydrosphingosine
  • Common Name:D-erythro-Sphinganine, C20 chain
  • Empirical Formula:C20H43NO2
  • CAS#:24006-62-0
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:330
  • Unit:5 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC, identity confirmed by MS
  • Solubility:chloroform/methanol, 5:1; warm ethanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

This product is the natural D-erythro isomer of dihydrosphingosine. Sphinganine (dihydrosphingosine) is the precursor of dihydroceramide which is then desaturated to form ceramide. It is a critical intermediate in the synthesis of many complex sphingoid bases and ceramide analogs. It has been found that sphinganine can induce cell death in a number of types of malignant cells and is being tested for its pharmacological properties.1 Inhibition of dihydroceramide synthesis by some fungal toxins that have a similar structure causes an increase in sphinganine and sphinganine-1-phosphate and a decrease in other sphingolipids leading to a number of diseases including oesophageal cancer.2 Sphinganine has been found to mediate fumonisin (a toxic sphinganine analog) induced hypotension.3 In yeast the amount of C20-dihydrosphingosine increases as a response to heat stress along with other sphingolipids, indicating that it is involved in heat stress adaptation.

1. W. Zheng “Fenretinide increases dihydroceramide and dihydrosphingolipids due to inhibition of dihydroceramide desaturase” Georgia Institute of Technology, 2006
2. L. van der Westhuizen et al. “Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study” Food Additives and Contaminants, Vol. 25(11), pages 1385 – 1391, 2008
3. Shih-Hsuan Hsiao et al. “Effects of Exogenous Sphinganine, Sphingosine, and Sphingosine-1-Phosphate on Relaxation and Contraction of Porcine Thoracic Aortic and Pulmonary Arterial Rings” Toxicological Sciences, Vol. 86(1) Pp. 194-199, 2005
Price $245.00

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