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Disialoganglioside GD1b (NH4+salt), porcine

CATALOG # 1547


  • Catalog #:1547
  • Scientific Name:Disialoganglioside GD1b (NH4+salt), porcine
  • Common Name:GD1b
  • Empirical Formula:C84H148N4O39•2NH3 (stearoyl; d18:1 sphingoid base)
    Typical fatty acid content
  • CAS#:19553-76-5
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1838+2NH3 (stearoyl; d18:1 sphingoid base)
  • Unit:1 mg
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Natural Source:porcine
  • Solubility:chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

As this product is derived from a natural source, there may be variations in the sphingoid backbone.

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.2 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. High levels of GD1b are found in the gliomas and astrocytomas. It can inhibit the efflux of K+ through K+ channels which results in the suppression of apoptosis.3 GD1b acts as a bacterial toxin receptor for tetanus and botulinus as well as for the BK virus.4

1. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
2. S. Birkle, G. Zeng, L. Gao, R.Yu, and J. Aubry “Role of tumor-associated gangliosides in cancer progression” Biochimie, 85, 455–463, 2003
3. X. Chen et al. “Inhibitory effect of ganglioside GD1b on K+ current in hippocampal neurons and its involvement in apoptosis suppression” Journal of Lipid Research, Vol. 46 pp. 2580-2585, 2005
4. K. Turton, J. Chaddock and K. Acharya “Botulinum and tetanus neurotoxins: structure, function and therapeutic utility” Trends in Biochemical Sciences, Vol. 27:11 pp. 552-558, 2002
Price $138.00

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