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CATALOG # 1846


  • Catalog #:1846
  • Scientific Name:L-erythro-Dihydrosphingosine
  • Common Name:L-erythro-Sphinganine, C18 chain
  • Empirical Formula:C18H39NO2
  • CAS#:6036-76-6
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:301
  • Unit:1 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC; identity confirmed by MS
  • Solubility:chloroform, methanol, ethanol, DMSO
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

This product is a high purity, well-defined, L-erythro-dihydrosphingosine which demonstrates unique properties as compared with the natural D-erythro isomer and is therefore ideal for use in studies of dihydrosphingosine. Natural D-erythrodihydrosphingosine is the precursor of dihydroceramide which is then desaturated to form ceramide. It is a critical intermediate in the synthesis of many complex sphingoid bases and ceramide analogs. It has been found that dihydrosphingosine can induce cell death in a number of types of malignant cells and it is being tested for its pharmacological properties.1 Whereas both D-threo and L-threo-C2-dihydroceramide induced apoptosis in cells neither Derythro nor L-erythro-C2-dihydroceramide showed activity.2 One report has concluded that all four of the enantiomers of dihydrosphingsoine act as substrates for sphingosine kinase with only the natural D-erythro-dihydrosphingosine being metabolized by sphinganine-1-phosphate lyase.3 However, another report concludes that only the erythro isomers of dihydrosphingosine act as substrates for this enzyme with both of the threo isomers inhibiting its activity.4

1. W. Zheng “Fenretinide increases dihydroceramide and dihydrosphingolipids due to inhibition of dihydroceramide desaturase” Georgia Institute of Technology, 2006
2. A. Bielawska “Selectivity of Ceramide-Mediated Biology Lack of Activity of erythro-Dihydroceramide” Journal of Biological Chemistry, vol. 268 pp. 26226-26232, 1993
3. W. Stoffel and K. Bister “Stereospecificities in the metabolic reactions of the four isomeric sphinganines (dihydrosphingosines) in rat liver” Hoppe Seylers Z Physiol Chem, vol. 354 pp. 169-181, 1973
4. B. Buehrer and R. Bell “Inhibition of Sphingosine Kinase in Vitro and in Platelets Implications for Signal Transduction Pathways” Journal of Biological Chemistry, vol. 267 pp. 3154-3159, 1992
Price $185.00

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