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Methyl 2-fluoropalmitate

CATALOG # 1718


  • Catalog #:1718
  • Scientific Name:Methyl 2-fluoropalmitate
    Activity: inactive ester of 2-fluoropalmitic acid
  • Common Name:Methyl 2-fluoropalmitate
    Activity: inactive ester of 2-fluoropalmitic acid
  • Empirical Formula:C17H33FO2
  • CAS#:137676-82-5
  • SDS:View Material Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:288
  • Unit:10 mg
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Melting Point:36-38°C
  • Solubility:chloroform,ethanol,methanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

This product is the inactive methyl ester of the acyl-CoA synthase inhibitor 2-fluoropalmitic acid. 2-Fluoropalmitic acid is a synthetic inhibitor of palmitoyl-CoA formation by long chain acyl-CoA synthetase thereby inhibiting sphingosine biosynthesis and protein palmitoylation. This product is very useful in the investigation of sphingosine synthesis1, protein acylation2, and other biological mechanisms3. Other alpha-fluoro-fatty acids also inhibit their respective acyl-CoAs.4

1. R. Soltysiak et al. “D,L-alpha-Fluoropalmitic acid inhibits sphingosine base formation and accumulates in membrane lipids of cultured mammalian cells” Biochim Biophys Acta, Vol. 792(2) pp. 214-226, 1984
2. J. Zhang et al. “Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signaling” Journal of Biochemistry, Vol. 343, 541-549, 1999
3. G. DeJesus and O. Bizzozero “Effect of 2-Fluoropalmitate, Cerulenin and Tunicamycin on the Palmitoylation and Intracellular Translocation of Myelin Proteolipid Protein” Neurochemical Research, Vol. 27(12) pp. 1669-1675, 2002
4. M. Grillo et al. “Effect of alpha-Fluorination of Valproic Acid on Valproyl-S-Acyl-CoA Formation in Vivo in Rats” Drug Metabolism and Disposition, Vol. 29(9) pp. 1210-1215, 2001
Price $262.00

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