Application Notes:
This product is a high purity 3-hydroxy fatty acid methyl ester that is ideal as a standard and for biological systems. This odd
numbered fatty acid is unusual in many biological systems and can therefore often be used as a biomarker. 3-
Hydroxyheptadecanoic acid has been used to characterize certain bacteria such as some gliding bacteria.1 3-Hydroxy fatty
acids have been found to be converted to the omega-fatty acid by the enzyme CYP4F11 and then into dicarboxylic acids in
vivo.2 3-hydroxy fatty acids are used as biomarkers for fatty acid oxidative disorders of both the long- and short-chain 3-
hydroxy-acyl-CoA dehydrogenases.3,4
References:
1. P. Srisukchayakul et al. “Rapidithrix thailandica gen. nov., sp. nov., a marine gliding bacterium isolated from samples collected from the Andaman sea,
along the southern coastline of Thailand” IJSEM, vol. 57 pp. 2275-2279, 2007
2. M. Dhar et al. “Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11” Journal of Lipid Research, vol. 49,
pp. 612-624, 2008
3. P. Jones et al. “Improved Stable Isotope Dilution-Gas Chromatography-Mass Spectrometry Method for Serum or Plasma Free 3-Hydroxy-Fatty Acids and
Its Utility for the Study of Disorders of Mitochondrial Fatty Acid beta-Oxidation” Clinical Chemistry, vol. 46, pp. 149-155, 2000
4. P. Jones et al. “Accumulation of free 3-hydroxy fatty acids in the culture media of fibroblasts from patients deficient in long-chain l-3-hydroxyacyl-CoA
dehydrogenase: a useful diagnostic aid” Clinical Chemistry, vol. 47(7) pp. 1190-1194, 2001