Application Notes:
This 3-hydroxynonanoic acid methyl ester is a high purity standard that is ideal for analysis and biological systems. 3-
Hydroxy fatty acids are intermediates in fatty acid biosynthesis and have been found to be converted to the omega-fatty acid
by the enzyme CYP4F11 and then into dicarboxylic acids in vivo.1 3-Hydroxy fatty acids are used as biomarkers for fatty
acid oxidative disorders of both the long- and short-chain 3-hydroxy-acyl-CoA dehydrogenases.2 Polyhydroxyalkenoates,
polyesters produced by bacteria fermentation, are used for carbon and energy storage and are of interest in studies regarding
their synthesis, properties and mechanisms and are used as biodegradable plastics.3 Medium chain-length
polyhydroxyalkenoate monomers may have pharmaceutical properties.
References:
1. M. Dhar et al. “Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11” Journal of Lipid Research, vol. 49,
pp. 612-624, 2008
2. P. Jones et al. “Accumulation of free 3-hydroxy fatty acids in the culture media of fibroblasts from patients deficient in long-chain l-3-hydroxyacyl-CoA
dehydrogenase: a useful diagnostic aid” Clinical Chemistry, vol. 47(7) pp. 1190-1194, 2001
3. J. Gangoiti et al. “Production of Chiral (R)-3-Hydroxyoctanoic Acid Monomers, Catalyzed by Pseudomonas fluorescens GK13 Poly(3-Hydroxyoctanoic
Acid) Depolymerase” Applied and Environmental Microbiology, vol. 76 pp. 3554-3560, 2010