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N-Tetracosenoyl-(cis-15)-monosialoganglioside GM2 (NH4+ salt)

CATALOG # 1572


  • Catalog #:1572
  • Scientific Name:N-Tetracosenoyl-(cis-15)-monosialoganglioside GM2 (NH4+ salt)
  • Common Name:N-Tetracosenoyl-GM2; N-Nervonyl-GM2; N-C24:1-GM2
  • Empirical Formula:C73H131N3O26• NH3 (d18:1 sphingoid base)
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1467 + NH3 (d18:1 sphingoid base)
  • Unit:100 µg
  • Source:semisynthetic
  • Purity:98+%
  • Analytical Methods:TLC, identity confirmed by MS
  • Natural Source:bovine
  • Solubility:Chloroform/Methanol/DI water 2:1:0.1; forms micellular solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:no
  • Hazardous:no


Application Notes:

As this product is derived from a natural source, there may be variations in the sphingoid backbone.

Gangliosides1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.2 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.3 The accumulation of gangliosides has been linked to several diseases including Tay-Sachs and Sandhoff disease. An autoimmune response against gangliosides can lead to Guillain-Barre syndrome.

L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
T. Kolter, R. Proia, K. Sandhoff, Combinatorial Ganglioside Biosynthesis. J. Biol. Chem., July Vol. 277, No. 29, pp. 25859-25862, 2002
S. Birkle, G. Zeng, L. Gao, R. K. Yu, and J. Aubry. Role of tumor-associated gangliosides in cancer progression. Biochimie, 85, 455–463, 2003
Price $259.00

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