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N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt)

CATALOG # 2051

Specifications

  • Catalog #:2051
  • Scientific Name:N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt)
  • Common Name:N-CD3-Stearoyl-GM2
  • Empirical Formula:C67H118D3N3O26•NH3 (d18:1 sphingoid base)
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:1388+NH3 (d18:1 sphingoid base)
  • Unit:250 ug
  • Source:semisynthetic, human Tay-Sachs
  • Purity:98+%
  • Analytical Methods:TLC, identity confirmed by MS
  • Solubility:chloroform/methanol/water, 2:1:0.1; forms micellar solution in water
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

As this product is derived from a natural source, there may be variations in the sphingoid backbone.

This deuterated ganglioside is ideal for the identification of gangliosides in samples and biological systems using mass spectrometry.1 Gangliosides2 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system.3 They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis, and metastasis.4 GM2 regulates the function of ciliary neurotrophic factor receptors. The accumulation of GM2 (due to a deficiency in beta-hexosaminidase) has characterized Tay-Sachs disease (due to a mutation in the gene HEXA) and Sandhoff disease (due to a mutation in the gene HEXB). A mutation in the GM2A gene results in GM2 activator deficiency that also leads to accumulation of GM2.5

References:
1. J. Gu, C. Tifft and S. Soldin “Simultaneous quantification of GM1 and GM2 gangliosides by isotope dilution tandem mass spectrometry” Clinical Biochemistry, Vol. 41(6) pp. 413-417, 2008
2. L. Svennerholm, et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980
3. T. Kolter, R. Proia, K. Sandhoff “Combinatorial Ganglioside Biosynthesis” J. Biol. Chem., Vol. 277, No. 29, pp. 25859-25862, 2002
4. S. Birkle, G. Zeng, L. Gao, R.K. Yu, and J. Aubry “Role of tumor-associated gangliosides in cancer progression” Biochimie, Vol. 85 pp. 455–463, 2003
5. R. Gravel et al., The Metabolic and Molecular Bases of Inherited Disease (C. R. Scriver, W. S. Sly, B. Childs, A. L. Beaudet, D. Valle, K. W. Kinzler, and B. Vogelstein, eds) pp. 3827–3876, McGraw-Hill Inc., New York, 2001
Price $583.00

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