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Royal Jelly acid

CATALOG # 1754


  • Catalog #:1754
  • Scientific Name:Royal Jelly acid
  • Common Name:10-Hydroxy-2-(E)-decenoic acid; omega-Hydroxy C10:1(2- trans) fatty acid; 10-HDA
  • Empirical Formula:C10H18O3
  • CAS#:14113-05-4
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:186
  • Unit:50 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC; identity confirmed by MS
  • Melting Point:63-65°C
  • Solubility:chloroform, ethanol, methanol
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No


Application Notes:

Royal Jelly acid (10-HDA) is one of the major fatty acids found in royal jelly, a substance secreted by young worker bees and fed to larvae. 10-HDA is being investigated for its pharmacological activities in treating several diseases, improving fertility, and preventing the spread of tumors. Hydroxy, saturated, and phosphoric acid esters of 10-HDA have also been found in Royal Jelly and these may also play a role in the pharmacological activities that have been cited.1 10-HDA promotes neurogenesis of neural stem/progenator cells, cells capable of differentiating into neurons, astrocytes, or oligodendrocytes, and could provide an effective method to treat and prevent neurological disorders.2 10-HDA also promotes the production of collagen and collagen promoting growth factors, potentially making it useful for therapeutic and cosmetic applications.3 10- HDA has been found to inhibit vascular endothelial growth factor which is a key regulator of normal and pathological angiogenesis and this could be used as a therapeutic treatment for retinopathies, rheumatoid arthritis, and tumor growth.4 Antibiotic actions have long been associated with 10-HDA and recently it has been confirmed to have good antibacterial properties.5

1. N. Noda et al. “Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera)” Lipids, Vol. 40(8) pp. 833-838, 2005
2. N. Hattori et al. “Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro” Biomedical Research, Vol. 28(5) pp. 261-266, 2007
3. S. Koya-Miyata et al. “Identification of a Collagen Prodcution-Promoting Factor from an Extract of Royal Jelly and Its possible Mechanism” Biosci Biothechnol Biochem, Vol. 68, 767-773, 2004
4. H. Izuta et al. “10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells” eCAM, Vol. 6(4) pp. 489-494, 2009
5. K. Yatsunami and T. Echigo “Antibacterial Action of Royal Jelly” Bull. Fac. Agr., no. 25 pp. 13-22, 1985
Price $297.00

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