Application Notes:
This product is a high purity sphingomyelin extracted from bovine buttermilk. Sphingomyelin is found in mammalian cell
membranes, especially in the membranes of the myelin sheath. It is the most abundant sphingolipid in mammals and is
thought to be found mostly in the exoplasmic leaflet of the membrane although there is also evidence of a sphingomyelin
pool in the inner leaflet of the membrane. It is involved in signal transduction and apoptosis.1 An improper ratio of
sphingomyelin to ceramide has been shown to be a factor in Niemann-Pick disease2 and neonatal respiratory distress
syndrome.3 However, the ratio of sphingomyelin to ceramide is different for different cell types.4 Sphingomyelin is an
important amphiphilic component when plasma lipoprotein pools expand in response to large lipid loads or metabolic
abnormalities.5
References:
1. R. N. Kolesnick, A. Haimovitz-Friedman, Z. Fuks “The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and
ionizing radiation” Biochem Cell Biol., Vol. 72(11-12) pp. 471-474, 1994
2. M. Schmuth, et al. “Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis”
J Invest Dermatol., Vol. 115(3) pp. 459-466, 2000
3. C. St Clair et al. “The probability of neonatal respiratory distress syndrome as a function of gestational age and lecithin/sphingomyelin ratio” Am J
Perinatol., Vol. 25(8) pp. 473-480, 2008,
4. J. Kilkus et al. “Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons” J Neurochem. Vol. 106(4) pp. 1745-
1757, 2008
5. N. Duan RD. “Absorption and lipoprotein transport of sphingomyelin” J Lipid Res., Vol. 47(1) pp. 154-171, 2006