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Sphingomyelin, bovine spinal cord

CATALOG # 1051

Specifications

  • Catalog #:1051
  • Scientific Name:Sphingomyelin
  • Common Name:SPM; Ceramide-1-phosphorylcholine
  • Empirical Formula:C41H83N2O6P (stearoyl) Typical fatty acid content
  • CAS#85187-10-6
  • SDSView Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:731 (stearoyl)
  • Unit:25 mg
  • Source:natural
  • Purity:98+%
  • Analytical Methods:TLC; identity confirmed by MS
  • Natural Source:bovine spinal cord
  • Solubility:ethanol, methanol, chloroform
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

Sphingomyelin is found in mammalian cell membranes, especially in the membranes of the myelin sheath. It is the most abundant sphingolipid in mammals and is thought to be found mostly in the exoplasmic leaflet of the membrane although there is also evidence of a sphingomyelin pool in the inner leaflet of the membrane. It is involved in signal transduction and apoptosis.1 An improper ratio of sphingomyelin to ceramide has been shown to be a factor in Niemann-Pick disease2 and neonatal respiratory distress syndrome.3 However, the ratio of sphingomyelin to ceramide is different for different cell types.4 Sphingomyelin is an important amphiphilic component when plasma lipoprotein pools expand in response to large lipid loads or metabolic abnormalities.5

References:
1. R. N. Kolesnick, A. Haimovitz-Friedman, Z. Fuks, Biochem Cell Biol., Vol. 72(11-12) pp. 471-474, 1994
2. M. Schmuth, et al., J Invest Dermatol., Vol. 115(3) pp. 459-466, 2000
3. C. St Clair et al., Am J Perinatol., Vol. 25(8) pp. 473-480, 2008,
4. J. Kilkus et al., J Neurochem. Vol. 106(4) pp. 1745-1757, 2008
5. N. Duan RD., J Lipid Res., Vol. 47(1) pp. 154-171, 2006
Price $70.00

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