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cis-9,10-Methyleneoctadecanoic acid

CATALOG # 1822

Specifications

  • Catalog #:1822
  • Scientific Name:cis-9,10-Methyleneoctadecanoic acid
  • Common Name:Dihydrosterculic acid
  • Empirical Formula:C19H36O2
  • CAS#:4675-61-0
  • SDS:View Safety Data Sheet
  • Data Sheet:View Data Sheet
  • Formula Weight:297
  • Unit:25 mg
  • Solvent:none
  • Source:synthetic
  • Purity:98+%
  • Analytical Methods:TLC, GC
  • Melting Point:38-42°C
  • Solubility:chloroform, ethanol, methanol, hexane
  • Physical Appearance:solid
  • Storage:-20°C
  • Dry Ice:No
  • Hazardous:No

Description

Application Notes:

This cyclopropanoid fatty acid is a major constituent of some seed oils and also occurs in some bacterial membranes but is not synthesized or used by humans.1 Dihydrosterculic acid is a major constituent of the phospholipids of many trypanosomatid flagellates including some pathogenic species. 10-thiastearic acid has been found to be a potent inhibitor of dihydrosterculic acid synthesis and has been used as a therapeutic drug against these organisms.2 The enzyme Sadenosylmethionine donates a methylene group to oleic acid in the sn-1 position of phosphatidylethanolamine to form dihydrosterculic acid. Dihydrosterculic acid is further desaturated to sterculic acid by cyclopropane desaturase.

References:
1. G. Knothe “NMR Characterization of Dihydrosterculic Acid and Its Methyl Ester” Lipids, Vol. 41(4) pp. 393-396, 2006
2. R. Pascal, Jr, S. Mannarelli, D. Ziering “10-Thiastearic acid inhibits both dihydrosterculic acid biosynthesis and growth of the protozoan Crithidia fasciculate” The Journal of Biological Chemistry, Vol. 261 pp. 12441-12443, 1986
Price $250.00

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